Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>

Physical needs and pharmacology regarding curcumin

Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin is the significant part of the latest red color of turmeric, an enthusiastic Indian liven that is extracted from the fresh new rhizome of your warm bush Curcuma longa, and therefore is one of the Zingiberaceae loved ones. Contained in this section, we discuss the pharmacological products out-of curcumin and you can explore the latest molecular angles of these things. We next remark brand new demonstrated and possible medical spends out-of curcumin. Curcumin known over the years since the a restorative representative, however, its method out of step is actually detailed. This new pharmacological negative effects of curcumin appear to be the consequence of a synergism away from systems regarding weak biochemical relationships which have several biological plans into the interconnected signaling routes. This type of targets tend to be minerals such as for instance cyclooxygenase, lipoxygenase and necessary protein kinases, and you will transcription issues instance NF-?B, STAT and you may Nrf2. Modulation ones molecules impacts downstream affectors that make this new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you will antimicrobial products of curcumin. These types of effects had been checked out inside systematic trials from curcumin getting aches and you can inflammatory ailment, cancer tumors, Alzheimer condition, cardiovascular problems, and you can diabetes. Brand new products used varying dosage regarding curcuminwith various other frequencies and you can cycle, for the standard completion you to high dosages from curcumin during the level of g have to receive healing effects. Read more

Curcumin: Synthesis, Emerging Character in the Problems Administration and you will Health Ramifications

Publication Section Samples of plant-derived pharmaceuticals having become the desire away from continuing and you may exponential search and you can creativity interest features, to date, been somewhat scarce. Shortly after several years, the final 2 decades was basically characterized by a great 100-flex increase in the amount of medical posts composed a-year you to definitely is actually of value with the access to curcumin during the biomedicine. Find out more

Build, synthesis and you will physical affairs of curcumin prodrugs

Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has many potential pharmacological consequences and may even enjoys healing software in a lot of state claims, given that chatted about in more detail in the last section. Yet not, the possibility medical effectiveness of curcumin is restricted by the the physicochemical properties from worst h2o solubility and you will imbalance, hence end in christian filipina datum reasonable bioavailability. Prodrugs of curcumin bring an approach to improve of biopharmaceutical and you may pharmacokinetic services, that can ensure it is exploitation of pharmacological aftereffects of curcumin. Contained in this section, i basic feedback new physicochemical and pharmacokinetics regarding curcumin. I then describe the design of curcumin prodrugs with improved water solubility and you may enhanced chemicals stability that may be translated back to 100 % free curcumin through to bioactivation during the vivo. We high light current achievements here, having a concentrate on the design, synthesis and you will review of prodrugs predicated on promoieties also amino acids, efas, nucleic acids, dicarboxylic acids, and you will polymeric material including hyaluronic acid and you may polyethylene glycol. Which chapter gets the cause for optimisation of the physicochemical and biopharmaceutical properties and physical affairs of curcumin prodrugs, into objective playing with ones curcumin derivatives in clinical programs. Read more